Chi-Huey Wong Assesses the Progress of the Vaccine for Globo-H Cancer

Globo H is a tumour-associated carbohydrate antigen found in epithelial cells

La Jolla, CA - September 11, 2019 /MarketersMedia/ —

The World Health Organization (WHO) reported in 2018 that the 2nd cause of death on a worldwide level is cancer, with the Ischaemic heart disease being 1st. Almost 10 million people die every year due to cancer, and 70% of them live in low to middle-income countries. Most of these cancers attack lungs, breasts, colon, stomach, prostate, liver and pancreas. Acclaimed biochemist Professor Chi-Huey Wong, PhD has worked tirelessly over the course of his career in advanced research to develop effective immunotherapy treatment regimens targeting the most prevalent types of cancerous tumor growth. After more than 30 years of research conducted out of labs based in the USA, Japan and Taiwan, Dr.Wong is particularly excited by the prospects for effective therapy and suppression of cancer cells and their stem cells through the application of Globo H vaccinations.

Globo H is a tumour-associated carbohydrate antigen found in epithelial cells (plasma membrane) that was first isolated in 1983 and observed to be expressed across a variety of cancers. Its complex chemistry made it highly difficult to replicate for study, until Chi-Huey Wong designed the Optimer One-Pot Synthesis (OPopS) which allowed for a complete and rapid synthesis of Globo H and the development of one of the first carbohydrate-based cancer vaccines, specifically targeting breast cancer cells and demonstrating positive results through Phase I and II human trials. The vaccine is currently in phase III global trials conducted by the Taiwaness biopharmaceutical company OBI Pharma, Inc.

A proliferation of Globo H studies published in journals such as the US National Library of Medicine, The Journal of Ovarian Research, The National Academy of Sciences and the American Chemical Society (which published Dr.Wong’s seminal pieces “Development of Globo H Vaccine” and “Functional Study and Signaling Pathway of Globo-series Glycosphingolipids and β1,3-Galactosyltransferase V (β3GalT5) in Breast Cancer”, Proc. Nat. Acad. Sci. U.S.A., 2019, 116, 3518-23) have shown promising data indicating the role and signaling mechanism of the globo-series glycolipids in cancer progression, and the positive efficacy correlation with these markers present in many leading cancer types. These studies and human trials support not only the continued research and application of vaccination technologies, but will also serve to aid in preventive screening and identifications.

Beginning in 2018, OBI has been conducting FDA-approved Phase I clinical trials of a “novel first-in-class monoclonal antibody”—OBI 888, specifically geared as a tumour-killer that targets Globo H and has shown efficacy at shrinking cancerous growths with no adverse effects to patients. New York-based Creative Biolabs are also demonstrating major advances in similar immunotherapies, offering primary and secondary prevention regimens based on antigens found in breast and prostate cancers and small cell lung carcinomas.

With a career spanning more than three decades beginning with an M.S. in Biochemical Sciences from the National Taiwan University in 1977, a PhD in Chemistry from MIT in 1982 and a Postdoctoral Fellowship from Harvard University in 1983, Chi-Huey Wong is recognized as a pioneer in the fields of glycoscience, organic chemistry and chemical biology and has published more than 700 academic research papers as reported by Asian Scientist Newsroom. Among his many accolades are the 2015 Robert Robinson Award from the Royal Society of Chemistry, the 2014 Wolf Prize in Chemistry (cited as the most prestigious award after the Nobel Prize) and the 2012 Nikkei Prize in Science, Technology and Innovation Category. Dr.Wong currently serves as the Scripps Family Chair Professor of Chemistry at the Scripps Research Institute in California and has previously held distinguished positions with the Academia Sinica in Taiwan and the RIKEN Institute of Physical and Chemical Research in Japan.

Chi-Huey Wong On the Importance of Glycan Microarrays for Understanding Immunity:

Chi-Huey Wong Examines Methods of Automation in Oligosaccharides Synthesis:

Contact Info:
Name: CHW
Email: Send Email
Organization: Chi-Huey Wong

Source URL:

Source: MarketersMedia

Release ID: 88918048

Latest News

Soleimani, a general who became Iran icon by targeting US

Feb 16, 2020

TEHRAN, Iran — For Iranians whose icons since the Islamic Revolution have been stern-faced clergy, Maj. Gen. Qassem Soleimani widely represented a figure of national resilience in the face of four decades of U.S. pressure. For the U.S. and Israel, he was a shadowy figure in command of Iran's proxy forces, responsible for fighters in Syria backing President Bashar Assad and for the deaths of American troops in Iraq. Solemani survived the horror of Iran’s long war in the 1980s with Iraq to take control of the Revolutionary Guard’s elite Quds Force, responsible for the Islamic Republic’s foreign campaigns. Relatively...

Muslim hajj pilgrims ascend Mount Arafat for day of worship

Feb 16, 2020

MOUNT ARAFAT, Saudi Arabia — More than 2 million Muslims are gathered at the sacred hill of Mount Arafat in Saudi Arabia for an intense day of worship and reflection on what's considered the climax of the Islamic hajj pilgrimage. Some had tears streaming down their faces as the men, wearing simple white garments, and women raised their hands in worship on the slopes of the rocky hill. Many walked through the pre-dawn darkness early Saturday to the hill where the Prophet Muhammad delivered his final sermon some 1,400 years ago, calling for equality and unity among Muslims. One of...

Saudi changes allow women to travel without male consent

Feb 16, 2020

DUBAI, United Arab Emirates — Saudi Arabia published new laws early Friday that loosen restrictions on women by allowing any citizen to apply for a passport and travel freely, ending a long-standing guardianship policy that gave men control over women. The changes are a potential game-changer for Saudi women's rights in the kingdom. The legal system has long been criticized because it treated women as minors throughout their adult lives, requiring they have a man's consent to obtain a passport or travel abroad. Often a woman's male guardian is her father or husband, and in some cases a woman's own...

The Latest: UN chief calls for 'maximum restraint' in Gulf

Feb 16, 2020

DUBAI, United Arab Emirates — The Latest on the tensions between the United States and Iran (all times local): 10:45 p.m. U.N. Secretary-General Antonio Guterres is again calling for "maximum restraint" in the Persian Gulf region and warning all parties that a new confrontation "would be a catastrophe." U.N. deputy spokesman Farhan Haq reiterated the U.N. chief's plea to avoid any escalation when asked Thursday for Guterres' reaction to Britain saying Iranian vessels tried to block one of its oil tankers in the Gulf. Haq said the U.N. hopes all nations "will take steps to avoid" an escalation and confrontation....

Egypt demands Christie's halt auction of King Tut statue

Feb 16, 2020

CAIRO — Egypt has tried to halt the auction of a 3,000-year-old stone sculpture of the famed boy pharaoh Tutankhamun at Christie's in London, while the auction house said its sale was legal. The statue — a brown quartzite head depicting King Tut — is scheduled to be auctioned off in July, and could generate more than $5 million, according to Christie's. The artifact features King Tut's full mouth with slightly drooping lower lips and almond-shaped eyes. For many, King Tut is the ultimate symbol of ancient Egypt's glory. Howard Carter discovered the pharaoh's nearly intact tomb in 1922 in...

About Us

Originally founded in 2015, Voyage Times publishes articles on travel and lifestyle for travelers, leisure seekers, and culture hunters from around the world.

Contact us: sales[at]

Subscribe Now!

Quick Links